Improving Vaccine Safety Through a Better Understanding of Vaccine Adverse Events

摘要: To the Editor—“I am worried that my child will get this serious side effect if she is vaccinated” a common concern raised by parents of infants and toddlers. Since vaccines are generally very safe, many these concerns can be assuaged. However, few vaccinated children experience adverse events. While current major public health benefit, history has taught us even slightest over event, perceived or real, inherent capacity to compromise confidence in specific vaccine vaccination general [1]. Thus, we should strive pursue avenues research could improve safety further. How do acquire knowledge? there examples epidemiologic studies identifying risk factors for events [2, 3], effort put into expanding substantially on findings translating them clinically useful scores. Additionally, it been suggested genetic influence propensity developing [4]. Indeed, preliminary work supports concept, with 2 candidate-gene reporting associations between variants certain immune system genes such as fever following smallpox [5, 6]. We recently conducted genome-wide association study investigate determinants febrile seizures occur measles, mumps, rubella (MMR) [7]. Between 3 16 excess cases per 10 000 attributed MMR, representing one most overall. As compared controls without seizures, loci harbor innate immunity IFI44L CD46 were associated MMR-related at significance level. an interferon-stimulated gene known upregulated viral infection including measles. encodes membrane protein several functions confirmed action cellular receptor measles virus. The encompassing specifically seizures; ie, significant observed vs well unrelated MMR (Table ​(Table1).1). An additional 4 significantly overall, ANO3, SCN1A, SCN2A, locus related magnesium regulation, pointing importance altered ion channel function seizure susceptibility. Table 1. Genetic Variants Distinctly Associated With Febrile Seizures Following Measles, Mumps, Rubella Vaccination While much remains elucidate how interaction their products lead results provide firm evidence Further, they open up novel toward personalized medicine vaccinology, field focused population level alone. For instance, envision clinical future where information data regarding other biomarkers integrated variables derive individualized scores predict ability design new completely free from come knowledge mechanisms currently available vaccines.