AngiostatinTM and EndostatinTM:endothelial cell-specific endogenous inhibitorsof angiogenesis and tumor growth

摘要: Angiostatin and Endostatin are potent inhibitors of angiogenesis. These proteins endogenously produced specifically target endothelial cells resulting in angiogenesis inhibition. Recombinant preparations these inhibit the growth metastases regress primary tumors to dormant microscopic lesions. A variety murine as well human breast, prostate colon xenograft models when treated with or Endostatin. Regression upon systemic treatment is part due increased tumor cell apoptosis. Repeated cycles therapy lead prolonged dormancy without further not associated any apparent toxicity acquired drug resistance