Angiostatin: an endogenous inhibitor of angiogenesis and of tumor growth.

摘要: Angiostatin, an internal fragment of plasminogen, is a potent inhibitor angiogenesis, which selectively inhibits endothelial cell proliferation. When given systemically, angiostatin potently tumor growth and can maintain metastatic primary tumors in dormant state defined by balance proliferation apoptosis the cells. We identified while studying phenomenon inhibition mass have elucidated one mechanism for this phenomenon. In our animal model, almost completely suppresses its remote metastases. However, after removal, previously metastases neovascularize grow. present, suppressed circulating angiogenesis inhibitor. Serum urine from tumor-bearing mice, but not controls, specifically inhibit The activity copurifies with 38 kD plasminogen we sequenced named angiostatin. Human angiostatin, obtained limited proteolytic digest human has similar activities. Systemic administration intact blocks neovascularization tumors. here show that mouse mediated, at least part,