Specificity of Cerebellar Vermian Abnormalities in Autism: A Quantitative Magnetic Resonance Imaging Study
作者： Walter E. Kaufmann , Karen L. Cooper , Stewart H. Mostofsky , George T. Capone , Wendy R. Kates
DOI: 10.1177/08830738030180070501
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摘要: To gain insight into the specificity of cerebellar vermian abnormalities reported in autism, we conducted a magnetic resonance imaging (MRI) study boys with either two conditions associated Down syndrome and fragile X syndrome, compared idiopathic autism controls. The subjects, ranging age from 3 to 9 years, included 16 + 11 only; 13 10 autism; 22 Diagnosis was based on DSM-IV criteria, confirmed primarily by Autism Diagnostic Interview. T1-weighted midsagittal MRIs were used measure midline structures. Intracranial area, reflecting brain size, significantly smaller subjects syndrome. Therefore, all measures expressed as ratios intracranial area. Analysis covariance (covarying for IQ) demonstrated that posterior vermi (lobules VI—VII a...
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