Determination of 13 Organic Toxicants in Human Blood by Liquid-Liquid Extraction Coupling High-Performance Liquid Chromatography Tandem Mass Spectrometry.
作者： Aiying SONG
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摘要: Pesticides and antidepressants are frequently misused in drug-facilitated crime because of their toxicological effect easy-availability. Therefore, it is essential for the development a simple reliable method determination these organic toxicants biological fluids. Here, we report on an applicable by combination optimized liquid-liquid extraction (LLE) procedure high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to identify quantify dimethoate, omethoate, dichlorvos, carbofuran, fenpropathrin, diazepam, estazolam, alprazolam, triazolamm, chlorpromazine, phenergan, barbitone phenobarbital human blood. The demonstrated linear calibration curve range 20 - 500 μg/L (r > 0.994). accuracy evaluated recovery spiked at three different concentrations (50, 100 200 μg/L) was 58.8 83.1% with relative standard deviations (RSD) 3.7 7.4%. limits quantification ranged over 6.7 33.3 μg/L. This proved be reliable, thus successfully applied forensic toxicology.
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