Enhanced phenobarbital induction of liver microsomal drug-metabolizing enzymes in mice infected with murine hepatitus virus.
作者： R. Kato , Y. Nakamura , E. Chiesara
DOI: 10.1016/0006-2952(63)90063-7
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摘要: Abstract The effect of an infection in mice with a murin hepatitis virus Buescher type (MHVB) on the liver microsomal drug metabolizing enzymes is investigated, alone, as well combination phenobarbital pretreatment. A diphasic MHVB drug-metabolizing observed: enzyme activity slightly increased 12 hr after and markedly depressed 48–60 after. pretreatment enhanced infected or 24 previously. These results suggest that condition stimulated biosynthesis protein RNA may enhance phenobarbital.
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