Hepatic microsomal protein and cytochrome P-450 in BALB/c mice infected with Leishmania
作者： I. A. AL-MOFLEH , S. A. AL-KHUWAITIR , A. A. MAHMOUD , D. B. KYEGOMBE , A. S. AL-TUWAIJRI
DOI: 10.1111/J.1440-1746.1989.TB00855.X
关键词:
摘要: The effects of infection mice with Leishmania major on liver microsomal protein and cytochrome P-450 were examined. levels hepatic monitored at 6, 7, 9 12 weeks post-infection. results indicated that the amount unchanged throughout course L. major, despite high degree parasite proliferation in Kupffer cells marked reduction phagocytosis. current clearly indicate Leishmania-induced macrophage suppression has no inhibitory effect P-450.
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