Addendum to Chapter 2 Reproduction of Papovaviruses

摘要: It would appear from the discussion in previous sections that interaction between papovaviruses and their host cells is quite complex. Yet SV40 polyoma virus genomes are smalI, with a coding capacity for three to seven proteins. By isolating studying properties of conditionally lethai mutants, it was hoped particular biological could be directly related function specific viral proteins, these functions, turn, mapped on genome. This approach, has been particularly successful last years, largely through efforts several investigators who have isolated characterized large numbers temperature-sensitive (ts) mutants.