Viral Delivery Systems for CRISPR.
作者： Christine L. Xu , Merry Z. C. Ruan , Vinit B. Mahajan , Stephen H. Tsang
DOI: 10.3390/V11010028
关键词:
摘要: The frontiers of precision medicine have been revolutionized by the development Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR)/Cas9 as an editing tool. CRISPR/Cas9 has used to develop animal models, understand disease mechanisms, and validate treatment targets. In addition, it is regarded effective tool for genome surgery when combined with viral delivery vectors. this article, we will explore various mechanisms delivering into tissues cells, well benefits drawbacks each method. We also review history recent CRISPR vectors discuss their applications a powerful in furthering our exploration therapies.
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