Diabetes and Atherosclerosis

摘要: Macrovascular disease is the leading cause of mortality and morbidity in diabetes. The study factors that may uniquely contribute to accelerated development atherosclerosis diabetes has been an ongoing process for several years. However, concepts behind both pathogenic mechanisms trigger lead acute clinical events have drastically changed last two decades. It now fully accepted arteriosclerosis a chronic inflammatory not degenerative inevitably progresses with age. Also fact plaque rupture or erosion degree vessel obstruction responsible majority cardiovascular events. Diabetes most likely contributes enhances characteristic supporting this concept are studies showing atherectomy specimens from diabetic patients undergoing coronary symptomatic artery (CAD) larger content macrophages than without (1). In recent years, formation key event precedes both, endothelial dysfunction, being actively studied (Fig. 1).