The metabolic syndrome, smoking, and antibodies to oxidized LDL in 58-year-old clinically healthy men.

摘要: BACKGROUND AND AIM The aim was to examine whether the metabolic syndrome (as recently defined), its various components, and smoking were associated with circulating antibodies oxidized low-density lipoproteins (IgG- IgM-Ox-LDLAb) malondialdehyde-treated LDL IgM-MDA-LDLAb) (ELISA) in a population sample of clinically healthy 58-year-old men (n = 391). METHODS RESULTS peak particle size (gradient gel electrophoresis) antibody titers measured all patients. Trend analysis showed significantly higher IgG-Ox-LDLAb IgG-MDA-LDLAb across range none criteria defining 77), those > or 1 criterion 252) fulfilling 62), which remained after adjustment for smoking. plasma insulin, body mass index (BMI), waist/hip ratio (WHR) was, addition, related diastolic blood pressure, serum triglycerides small size. IgM only inversely correlated CONCLUSIONS High IgG MDA-treated Several factors modified LDL. high degree intercorrelation among these makes it difficult clarify independent role any specific factor.