Aurora kinase is required for chromosome segregation in tobacco BY-2 cells
作者： Daisuke Kurihara , Sachihiro Matsunaga , Akira Kawabe , Satoru Fujimoto , Masanori Noda
DOI: 10.1111/J.1365-313X.2006.02893.X
关键词:
摘要: Post-translational modifications of core histone tails play crucial roles in chromatin structure and function. Although phosphorylation Ser10 Ser28 (H3S10ph H3S28ph) H3 is ubiquitous among eukaryotes, the mechanism during cell cycle remains unclear. In present study, H3S10ph H3S28ph tobacco BY-2 cells were observed pericentromeric regions mitosis. Moreover, Aurora kinase inhibitor Hesperadin inhibited activity Arabidopsis thaliana 3 (AtAUR3) phosphorylating both vitro. Consistently, mitosis cells. These results indicate that plant kinases phosphorylate not only Ser10, but also vivo. treatment increased ratio metaphase cells, while anaphase/telophase decreased, although mitotic index was affected Hesperadin-treated suggest induces delayed transition from to anaphase, early exit after chromosome segregation. addition, micronuclei frequently lagging chromosomes, caused by delay failure sister chromatid separation, at anaphase telophase The data obtained here H3S10ph/H3S28ph may have a role segregation metaphase/anaphase transition.
sci-hub.se 参考文章(40)
Yan Li, Yana Butenko, Gideon Grafi, Histone deacetylation is required for progression through mitosis in tobacco cells. Plant Journal. ,vol. 41, pp. 346- 352 ,(2004) , 10.1111/J.1365-313X.2004.02301.X
Toshiyuki Nagata, Yasuyuki Nemoto, Seiichiro Hasezawa, Tobacco BY-2 Cell Line as the “HeLa” Cell in the Cell Biology of Higher Plants International Review of Cytology-a Survey of Cell Biology. ,vol. 132, pp. 1- 30 ,(1992) , 10.1016/S0074-7696(08)62452-3
Erich A. Nigg, Mitotic kinases as regulators of cell division and its checkpoints Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 21- 32 ,(2001) , 10.1038/35048096
Hidemasa Goto, Yoshihiro Yasui, Erich A. Nigg, Masaki Inagaki, Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes to Cells. ,vol. 7, pp. 11- 17 ,(2002) , 10.1046/J.1356-9597.2001.00498.X
Marko J. Kallio, Mark L. McCleland, P.Todd Stukenberg, Gary J. Gorbsky, Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis. Current Biology. ,vol. 12, pp. 900- 905 ,(2002) , 10.1016/S0960-9822(02)00887-4
Xiangyu Li, Gyosuke Sakashita, Hideki Matsuzaki, Kenji Sugimoto, Keiji Kimura, Fumio Hanaoka, Hisaaki Taniguchi, Koichi Furukawa, Takeshi Urano, Direct Association with Inner Centromere Protein (INCENP) Activates the Novel Chromosomal Passenger Protein, Aurora-C Journal of Biological Chemistry. ,vol. 279, pp. 47201- 47211 ,(2004) , 10.1074/JBC.M403029200
Masashi Kimura, Yoichi Matsuda, Takashi Yoshioka, Yukio Okano, Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. Journal of Biological Chemistry. ,vol. 274, pp. 7334- 7340 ,(1999) , 10.1074/JBC.274.11.7334
A. Houben, D. Demidov, T. Rutten, K.H. Scheidtmann, Novel phosphorylation of histone H3 at threonine 11 that temporally correlates with condensation of mitotic and meiotic chromosomes in plant cells Cytogenetic and Genome Research. ,vol. 109, pp. 148- 155 ,(2005) , 10.1159/000082394
Paul D Andrews, Elena Knatko, William J Moore, Jason R Swedlow, Mitotic mechanics: the auroras come into view. Current Opinion in Cell Biology. ,vol. 15, pp. 672- 683 ,(2003) , 10.1016/J.CEB.2003.10.013
Naoko Kunitoku, Takashi Sasayama, Tomotoshi Marumoto, Dongwei Zhang, Shinobu Honda, Osamu Kobayashi, Katsuyoshi Hatakeyama, Yukitaka Ushio, Hideyuki Saya, Toru Hirota, CENP-A Phosphorylation by Aurora-A in Prophase Is Required for Enrichment of Aurora-B at Inner Centromeres and for Kinetochore Function Developmental Cell. ,vol. 5, pp. 853- 864 ,(2003) , 10.1016/S1534-5807(03)00364-2