Non-Immunosuppressant Medication Use in Heart Transplant Patients: A Guide for Pharmacists

作者: Gregory Egan , Glen J. Pearson

DOI: 10.4236/PP.2014.510107

关键词:

摘要: For heart transplant patients, there are a number of non-immunosuppressant medications that routinely prescribed to mitigate the side-effects immunosuppression, treat related complications, and improve long-term survival. This review focuses on used prevent manage cardiac allograft vasculopathy (CAV), hypertension, dyslipidemia osteoporosis. The rationale evidence supporting their use summarized immunosuppressant drugs only discussed briefly, as they relate each these medical issues. Pharmacy practitioners likely encounter patients post-cardiac in variety clinical settings; therefore, concise appreciation principles for management is important when providing collaborative care.

参考文章(52)
Ignacio J. Sánchez-Lázaro, Luis Martínez-Dolz, Luis Almenar-Bonet, José A. Moro-López, Jaime Agüero, Víctor Ortiz-Martínez, María Teresa Izquierdo, A. Salvador, Predictor factors for the development of arterial hypertension following heart transplantation. Clinical Transplantation. ,vol. 22, pp. 760- 764 ,(2008) , 10.1111/J.1399-0012.2008.00875.X
Claire S Allen, James HS Yeung, Ben Vandermeer, Joanne Homik, Bisphosphonates for steroid induced osteoporosis Cochrane Database of Systematic Reviews. ,vol. 10, pp. 0- 0 ,(2016) , 10.1002/14651858.CD001347.PUB2
David O. Taylor, Mark L. Barr, Branislav Radovancevic, Dale G. Renlund, Robert M. Mentzer Jr, Frank W. Smart, David E. Tolman, O.H. Frazier, James B. Young, Paul VanVeldhuisen, A randomized, multicenter comparison of tacrolimus and cyclosporine immunosuppressive regimens in cardiac transplantation: decreased hyperlipidemia and hypertension with tacrolimus11This study was sponsored by a grant from Fujisawa USA, Deerfield, Illinois.22The authors were working on behalf of the Tacrolimus US Heart Transplant Multicenter Study Group. Other members of the Study Group included (principal investigator listed first): UTAH Cardiac Transplant Program, Salt Lake City, Utah: David O. Taylor, MD, Dale G. Renlund, MD, Abdallah G. Kfoury, MD; St. Luke’s Episcopal Hospital/Texas Heart Institute, Houston, Texas: O. H. Frazier, MD, Branislav Radovancevic, MD, Edward K. Massin, MD; University of Wisconsin Hospitals and Clinics, Madison, Wisconsin: Robert M. Mentzer, Jr., MD, Charles C. Canver, MD, Robert B. Love, MD; Ochsner Medical Foundation, New Orleans, Louisiana: Frank W. Smart, MD, Hector O. Ventura, MD, Dwight D. Stapleton, MD, Mandeep Mehra, MD; University of Southern California, Los Angeles, California: Mark L. Barr, MD, Vaugh A. Starnes, MD; Medical College of Virginia, Richmond, Virginia: David E. Tolman, MD, Albert Guerraty, MD, David Salter, MD; Cleveland Clinic Foundation, Cleveland, Ohio: James B. Young, MD; Data Management and Statistical Coordinating Center-The EMMES Corporation, Potomac, Maryland: Paul VanVeldhuisen, MS, Anne Lindblad, PhD, Anita Yaffe, MSN, MPH. The Journal of Heart and Lung Transplantation. ,vol. 18, pp. 336- 345 ,(1999) , 10.1016/S1053-2498(98)00060-6
P.N.M. Demacker, A.J. Hoitsma, L.B. Hilbrands, A.F.H. Stalenhoef, R.A.P. Koene, The effects of cyclosporine and prednisone on serum lipid and (apo)lipoprotein levels in renal transplant recipients. Journal of The American Society of Nephrology. ,vol. 5, pp. 2073- 2081 ,(1995) , 10.1681/ASN.V5122073
Michael Dandel, Roland Hetzer, Impact of Immunosuppressive Drugs on the Development of Cardiac Allograft Vasculopathy Current Vascular Pharmacology. ,vol. 8, pp. 706- 719 ,(2010) , 10.2174/157016110792006923
Devang N Patel, Francis D Pagani, Todd M Koelling, David B Dyke, Ragavendra R Baliga, Robert J Cody, Kathleen D Lake, Keith D Aaronson, Safety and efficacy of atorvastatin in heart transplant recipients Journal of Heart and Lung Transplantation. ,vol. 21, pp. 204- 210 ,(2002) , 10.1016/S1053-2498(01)00369-2
Jennifer T. Thibodeau, Joseph D. Mishkin, Parag C. Patel, Pradeep P.A. Mammen, David W. Markham, Mark H. Drazner, IIIB or Not IIIB: A Previously Unanswered Question Journal of Cardiac Failure. ,vol. 18, pp. 367- 372 ,(2012) , 10.1016/J.CARDFAIL.2012.01.016
Randy W. Braith, Peter M. Magyari, Michael N. Fulton, Clem F. Lisor, Sara E. Vogel, James A. Hill, Juan M. Aranda, Comparison of calcitonin versus calcitonin + resistance exercise as prophylaxis for osteoporosis in heart transplant recipients. Transplantation. ,vol. 81, pp. 1191- 1195 ,(2006) , 10.1097/01.TP.0000176927.43937.BB
Hannah A. Valantine, Shao-Zhou Gao, Santosh G. Menon, Dale G. Renlund, Sharon A. Hunt, Philip Oyer, Edward B. Stinson, Byron W. Brown, Thomas C. Merigan, John S. Schroeder, Impact of prophylactic immediate posttransplant ganciclovir on development of transplant atherosclerosis: a post hoc analysis of a randomized, placebo-controlled study. Circulation. ,vol. 100, pp. 61- 66 ,(1999) , 10.1161/01.CIR.100.1.61