Inhibition of Na+ Current by Diphenhydramine and Other Diphenyl Compounds: Molecular Determinants of Selective Binding to the Inactivated Channels

作者: Bih-Show Lou , Chung-Chin Kuo , Ron-Chi Huang

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摘要: … Na + current via selective binding to the inactivated Na + channel, and its binding affinity to … that to the inactivated channels. We also found that many other diphenyl compounds have a …

参考文章(32)
B. P. Bean, Chung-Chin Kuo, Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons. Molecular Pharmacology. ,vol. 46, pp. 716- 725 ,(1994)
R. E. Ten Eick, Jay Z Yeh, F. N. Quandt, N. Matsuki, Characterization of the block of sodium channels by phenytoin in mouse neuroblastoma cells. Journal of Pharmacology and Experimental Therapeutics. ,vol. 228, pp. 523- 530 ,(1984)
B R Cooper, D G Lang, C M Wang, Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. Journal of Pharmacology and Experimental Therapeutics. ,vol. 266, pp. 829- 835 ,(1993)
Francisco Riccioppo Neto, The local anesthetic effect of cyproheptadine on mammalian nerve fibres European Journal of Pharmacology. ,vol. 54, pp. 203- 207 ,(1979) , 10.1016/0014-2999(79)90078-5
Chung-Chin Kuo, Bruce P. Bean, Na+ channels must deactivate to recover from inactivation. Neuron. ,vol. 12, pp. 819- 829 ,(1994) , 10.1016/0896-6273(94)90335-2
Zhen Ming, Charles Nordin, Terfenadine blocks time-dependent Ca2+, Na+, and K+ channels in guinea pig ventricular myocytes. Journal of Cardiovascular Pharmacology. ,vol. 26, pp. 761- 769 ,(1995) , 10.1097/00005344-199511000-00013
Charles George Steffen, Richard Mihan, Murray Zimmerman, The Evaluation of Various Antihistamines as Local Anesthetic Agents1 Journal of Investigative Dermatology. ,vol. 29, pp. 7- 8 ,(1957) , 10.1038/JID.1957.66