Gene homologs on human chromosome 15q21-q26 and a chicken microchromosome identify a new conserved segment
作者： Cheryl T. Jones , David R. Morrice , Ian R. Paton , David W. Burt
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摘要: The genes for insulin-like growth factor 1 receptor (IGF1R), aggrecan (AGC1), β2-microglobulin (B2M), and an H6-related gene have been mapped to a single chicken microchromo-some by genetic linkage analysis. In addition, second was macrochromosome 3. Igf1r Agc1 loci are syntenic on mouse Chr 7, together with Hmx3, H6-like locus. This suggests that the locus, which maps microchromosome in this study, is homolog of Hmx3. IGF1R, AGC1, B2M located human 15, probably same order as found microchromosome. conserved segment, however, not entirely split between 7 (Igf1r-Age) 2 (B2m). comparison also predicts HMX3 locus may map short arm 15. segment defined IGF1R-AGC1-HMX3—B2M approximately 21–35 Mb length covers entire These results suggest 15 has micro-chromosome. significance result discussed reference evolution avian mammalian genomes.
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