Zooming in on the Human–Mouse Comparative Map: Genome Conservation Re-examined on a High-Resolution Scale

摘要: Over the past decade, conservation of genetic linkage groups has been shown in mammals and used to great advantage, fueling significant exchanges gene mapping functional information especially between genomes humans mice. As human physical maps increase resolution from chromosome bands nucleotide sequence, comparative alignments mouse regions have revealed striking similarities surprising differences these two best-mapped mammalian species. Whereas, at present, very few compared on level, existing studies provide intriguing insights genome evolution, including observation recent duplications deletions genes that may play roles defining some biological Although high-resolution conserved marker-based are currently available only for mouse, a variety new methods resources speeding development additional organisms. These advances mark first step toward establishment as reference map vertebrate species, providing evolutionary annotation sequence vast analysis commercially, medically, ecologically important animal models.