Effect of vascular endothelial growth factor siRNA and wild‑type p53 co‑expressing plasmid in MDA‑MB‑231 cells

摘要: Breast cancer urgently requires improved therapeutic strategies. In the current study, a Pvp53 plasmid that co‑expressed p53 and short‑interfering RNA against vascular endothelial growth factor (si‑VEGF) was developed to replace single transfections. Whether exhibited anti‑tumor effects in breast MDA‑MB‑231 cells investigated present study. significantly reduced Bcl‑2/Bax ratio increased expression of cleaved caspase‑3 8. Compared with si‑VEGF transfections, co‑expression proportion apoptotic inhibited cell motility proliferation. These results indicated has greater inhibitory on than plasmids.