Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process.
作者： Sophie Baveye , Elisabeth Elass , Joël Mazurier , Geneviève Spik , Dominique Legrand
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摘要: Lactoferrin is an iron-binding glycoprotein found in exocrine secretions of mammals and released from neutrophilic granules during inflammation. This review describes the biological roles lactoferrin host defence. Secreted exerts antimicrobial action either by chelation iron or destabilization bacterial membranes. Furthermore, modulates inflammatory process, mainly preventing release cytokines monocytes regulating proliferation differentiation immune cells. Some these activities are related to ability bind lipopolysaccharides (LPS) with high affinity. Indeed, recent vitro studies indicate that able compete LPS-binding protein for LPS binding therefore prevent transfer CD14 present at surface monocytes. Moreover, prophylactic properties against septicemia vivo have been demonstrated. Taken as a whole, observations strongly suggest one key molecules which modulate response.
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