Endocrine disruptors of inhibiting testicular 3β-hydroxysteroid dehydrogenase.
作者： Song Zhang , Jiaying Mo , Yiyan Wang , Chaobo Ni , Xiaoheng Li
DOI: 10.1016/J.CBI.2019.02.027
关键词:
摘要: Testicular 3β-hydroxysteroid dehydrogenase (HSD3B) is a steroidogenic enzyme, catalyzing the conversion of 3β-hydroxysteroids into 3-keto-steroids. Two distinct isoforms in human are cloned, HSD3B1 and HSD3B2, HSD3B2 located testis. two-substrate which binds to cofactor NAD+ 3β-steroid. Many endocrine disruptors, including industrial compounds (phthalates, bisphenols, perfluoroalkyl substances), insecticides biocides (organochlorine organotins), food additives (butylated hydroxyanisole, resveratrol, gossypol, flavones, isoflavones), drugs (etomidate, troglitazone, medroxyprogesterone acetate, ketoconazole) inhibit testicular HSD3B, possibly interfering with androgen synthesis. In this review, we discuss isoform its gene, chemistry, subcellular location, disruptors that directly HSD3B their inhibitory modes.
sci-hub.se 参考文章(101)
J C Chapman, L A Sauer, Intracellular localization and properties of 3 beta-hydroxysteroid dehydrogenase/isomerase in the adrenal cortex. Journal of Biological Chemistry. ,vol. 254, pp. 6624- 6630 ,(1979) , 10.1016/S0021-9258(18)50414-2
Yitao Pan, Jun Jing, Fengshou Dong, Qi Yao, Wei Zhang, Hongxia Zhang, Bing Yao, Jiayin Dai, Association between phthalate metabolites and biomarkers of reproductive function in 1066 Chinese men of reproductive age. Journal of Hazardous Materials. ,vol. 300, pp. 729- 736 ,(2015) , 10.1016/J.JHAZMAT.2015.08.011
WAITES, WANG, GRIFFIN, Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug. International Journal of Andrology. ,vol. 21, pp. 8- 12 ,(1998) , 10.1046/J.1365-2605.1998.00092.X
H F Zhao, C Labrie, J Simard, Y de Launoit, C Trudel, C Martel, E Rhéaume, E Dupont, V Luu-The, G Pelletier, Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase cDNAs and differential tissue-specific expression of the corresponding mRNAs in steroidogenic and peripheral tissues. Journal of Biological Chemistry. ,vol. 266, pp. 583- 593 ,(1991) , 10.1016/S0021-9258(18)52475-3
G.-X. Hu, B. Zhao, Y. Chu, X.-H. Li, B. T. Akingbemi, Z.-Q. Zheng, R. S. Ge, Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes. International Journal of Andrology. ,vol. 34, pp. 138- 144 ,(2011) , 10.1111/J.1365-2605.2010.01065.X
J Simard, J Couet, F Durocher, Y Labrie, R Sanchez, N Breton, C Turgeon, F Labrie, Structure and tissue-specific expression of a novel member of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) family. The exclusive 3 beta-HSD gene expression in the skin. Journal of Biological Chemistry. ,vol. 268, pp. 19659- 19668 ,(1993) , 10.1016/S0021-9258(19)36567-6
J. Simard, Y. de Launoit, F. Labrie, Characterization of the structure-activity relationships of rat types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5 -delta 4 isomerase by site-directed mutagenesis and expression in HeLa cells. Journal of Biological Chemistry. ,vol. 266, pp. 14842- 14845 ,(1991) , 10.1016/S0021-9258(18)98548-0
Slavisa Gasic, Manubi Nagamani, Allan Green, Randall J. Urban, Troglitazone is a competitive inhibitor of 3β-hydroxysteroid dehydrogenase enzyme in the ovary American Journal of Obstetrics and Gynecology. ,vol. 184, pp. 575- 579 ,(2001) , 10.1067/MOB.2001.111242
James L. Thomas, J. Ian Mason, Stacey Brandt, Byron R. Spencer, Wendy Norris, Structure/Function Relationships Responsible for the Kinetic Differences between Human Type 1 and Type 2 3β-Hydroxysteroid Dehydrogenase and for the Catalysis of the Type 1 Activity Journal of Biological Chemistry. ,vol. 277, pp. 42795- 42801 ,(2002) , 10.1074/JBC.M208537200
Eisuke P. Murono, Raymond C. Derk, The effects of the reported active metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, on testosterone formation by cultured Leydig cells from young adult rats. Reproductive Toxicology. ,vol. 19, pp. 135- 146 ,(2004) , 10.1016/J.REPROTOX.2004.06.010