An in silico approach to study the interaction of BHA with selected steroid hormone receptors and investigating it's agonistic and antagonistic properties.

摘要: Antioxidant food additives were routinely used for increasing the keeping quality of packaged items. Butylated Hydroxyanisole (BHA) is one most widely synthetic phenolic antioxidants such kind. Although quantity in eatables and admissible daily intake (ADI) per person day are limited by laws, urbanisation changes lifestyle has cross these limits. studies on BHA been carried out, there exists a great deal uncertainty about exact molecular mechanism interaction with various receptors body. Since earlier reports suggested plausibly interferes reproductive system development, we opted docking critical receptors of endogenous hormones controlling growth development BHA. Nuclear estrogen (ER), androgen (AR) progesterone (PR) selected this purpose. This manuscript describes comparison binding pattern towards AR, ER PR along their agonists antagonist. Lamarckian Genetic Algorithm AutoDock 4.0 was analysing mode ligands receptors. It evident form that, exhibited similar pattern` antagonists AR ER. But not compatible either or antagonists. The patterns produced could reliably demonstrate interactions also predict its possible agonistic antagonistic action.