Effects of butylated hydroxyanisole on the development and functions of reproductive system in rats.
作者： Sang-Hee Jeong , Byung-Yong Kim , Hwan-Goo Kang , Hyun-Ok Ku , Joon-Hyoung Cho
DOI: 10.1016/J.TOX.2004.11.014
关键词: Lactation 、 Estrous cycle 、 Sperm 、 Endocrinology 、 Offspring 、 Reproductive system 、 Internal medicine 、 Testosterone 、 Biology 、 Butylated hydroxyanisole 、 Follicular phase
摘要: Butylated hydroxyanisol (BHA) is a widely used antioxidant for long preservation of food products, cosmetics and pharmaceuticals. Although BHA is generally recognized as safe, it is classified as a suspected endocrine-disrupting compound. We investigated the effects of BHA on reproductive function and development by the treatment of mature male and female SD rats (F0) through pre-gestation, gestation and lactation period and of their offspring (F1) until 13 weeks old via gavage with BHA 0 (corn oil, vehicle control), 10, 100 and 500mg/kg …
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