Monohalogenated maleimides as potential agents for the inhibition of Pseudomonas aeruginosa biofilm

摘要: New monohalogenated maleimide derivatives (with bromine, chlorine or iodine) were synthesized to test the effect of halogen atoms in inhibiting formation Pseudomonas aeruginosa biofilm. The evaluation their biological activities clearly defines a structure–activity relationship. In this study, bactericidal action three compounds was observed at concentration range 0.3–5.0 mM on Luria-Bertani agar plates. atom these molecules critical modulating antibacterial activity, with slightly higher effectiveness for chlorine. Confocal laser scanning microscopy used examine P. biofilms cultivated flow cells. At as low 40 μM, bromine and iodine displayed total inhibition towards bacterial concentration, attachment glass surfaces strongly affected by presence whereas derivative behaved compound. A biolu...