Post-exposure antiviral treatment of norovirus infections effectively protects against diarrhea and reduces virus shedding in the stool in a mortality mouse model

摘要: Abstract Noroviruses are a leading cause of gastroenteritis across the world in all age groups and linked to increased hospitalization mortality children, elderly immunocompromised. The development specific antiviral treatment for norovirus is urgently needed. We explored mouse model whether an inhibitor replication could be used therapeutically post murine (MNV)-infection mice. Using MNV, we previously discovered that viral polymerase 2′-C-methylcytidine (2CMC) able protect against diarrhea mice when prophylactically block transmission MNV between Here, investigated 2CMC therapeutically, starting 12 h 3 days post-infection with 2CMC. Post-exposure MNV-infected was efficient up 2 after infection, preventing norovirus-induced diarrhea, delaying reducing shedding stool treated Rehydration 2CMC-treated animals did not result further improvement disease evolution compared only. presence antigens inflammation small intestine infected inversely correlated effectiveness delayed treatment. Anti-MNV IgGs were detected re-challenged 10 weeks first contact, these protected from re-infection. here demonstrate benefit ongoing infections.