Inhibitory Effects of Laminaria japonica Fucoidans Against Noroviruses.
作者： Hyojin Kim , Chae Yeon Lim , Dan Bi Lee , Jong Hyeon Seok , Kyung Hyun Kim
DOI: 10.3390/V12090997
关键词:
摘要: Norovirus is the leading cause of nonbacterial foodborne disease outbreaks. Human noroviruses (HuNoVs) bind to histo-blood group antigens as host receptor for infection. In this study, inhibitory effects fucoidans from brown algae, Laminaria japonica (LJ), Undaria pinnatifida and sporophyll, were evaluated against murine norovirus (MNoV), feline calicivirus (FCV) HuNoV. Pretreatment MNoV or FCV with at 1 mg/mL showed high antiviral activities, 1.1 average log reductions viral titers in plaque assays. They also significant inhibition on binding P domains HuNoV GII.4 GII.17 A- O-type saliva LJ fucoidan was most effective, reaching 54–72% mg/mL. STAT1−/− mice infected MNoV, oral administration fucoidan, composed mainly sulfated fucose minor amounts glucose galactose, improved survival rates significantly reduced their feces. Overall, these results provide can be used reduce NoV
mdpi.com
sci-hub.st 参考文章(51)
Huicheng Yang, Mingyong Zeng, Shiyuan Dong, Zunying Liu, Ruixue Li, Anti-proliferative activity of phlorotannin extracts from brown algae Laminaria japonica Aresch Chinese Journal of Oceanology and Limnology. ,vol. 28, pp. 122- 130 ,(2010) , 10.1007/S00343-010-9054-X
Anna D. Koromyslova, Peter A. White, Grant S. Hansman, Treatment of norovirus particles with citrate. Virology. ,vol. 485, pp. 199- 204 ,(2015) , 10.1016/J.VIROL.2015.07.009
M de Graaf, J van Beek, H Vennema, A T Podkolzin, J Hewitt, F Bucardo, K Templeton, J Mans, J Nordgren, G Reuter, M Lynch, L D Rasmussen, N Iritani, M C Chan, V Martella, K Ambert-Balay, J Vinjé, P A White, M P Koopmans, Emergence of a novel GII.17 norovirus – End of the GII.4 era? Eurosurveillance. ,vol. 20, pp. 21178- ,(2015) , 10.2807/1560-7917.ES2015.20.26.21178
Janet Fitton, Damien Stringer, Samuel Karpiniec, Therapies from Fucoidan: An Update Marine Drugs. ,vol. 13, pp. 5920- 5946 ,(2015) , 10.3390/MD13095920
M. A. Tabatabai, A Rapid Method for Determination of Sulfate in Water Samples Environmental Letters. ,vol. 7, pp. 237- 243 ,(1974) , 10.1080/00139307409437403
J Steinmann, Surrogate viruses for testing virucidal efficacy of chemical disinfectants. Journal of Hospital Infection. ,vol. 56, pp. 49- 54 ,(2004) , 10.1016/J.JHIN.2003.12.030
D. Manns, A. L. Deutschle, B. Saake, A. S. Meyer, Methodology for quantitative determination of the carbohydrate composition of brown seaweeds (Laminariaceae) RSC Advances. ,vol. 4, pp. 25736- 25746 ,(2014) , 10.1039/C4RA03537B
W. Mak, N. Hamid, T. Liu, J. Lu, W.L. White, Fucoidan from New Zealand Undaria pinnatifida: Monthly variations and determination of antioxidant activities Carbohydrate Polymers. ,vol. 95, pp. 606- 614 ,(2013) , 10.1016/J.CARBPOL.2013.02.047
Mi Oh, Ji-Hye Lee, Seon Young Bae, Jong Hyeon Seok, Sella Kim, Yeon Bin Chung, Kang Rok Han, Kyung Hyun Kim, Mi Sook Chung, Protective effects of red wine and resveratrol for foodborne virus surrogates Food Control. ,vol. 47, pp. 502- 509 ,(2015) , 10.1016/J.FOODCONT.2014.07.056
Peter F.M. Teunis, Christine L. Moe, Pengbo Liu, Sara E. Miller, Lisa Lindesmith, Ralph S. Baric, Jacques Le Pendu, Rebecca L. Calderon, Norwalk Virus: How Infectious Is It? Journal of Medical Virology. ,vol. 80, pp. 1468- 1476 ,(2008) , 10.1002/JMV.21237