Fucoidan but not 2'-Fucosyllactose could inhibit human norovirus replication in zebrafish larvae
作者： Malcolm Turk Hsern Tan , Yan Li , Mohamad Eshaghi Gorji , Zhiyuan Gong , Dan Li
DOI: 10.1101/2020.12.23.424093
关键词:
摘要: Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antivirals hitherto. In this study, with the use of a zebrafish larvae in vivo platform, we investigated anti-hNoV potentials fucoidan 29-Fucosyllactose (29-FL). As result, although both 2-9FL were able to block hNoV GII.4 virus-like particle (VLPs) from binding type A saliva as expected, only but not was inhibit replication GII.P16-GII.4 larvae, indicating possible needs higher molecular weights for fucosylated carbohydrates exert effect.
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