Photosensitizing properties of a boronated phthalocyanine: studies at the molecular and cellular level.
作者： Clara Fabris , Giulio Jori , Francesca Giuntini , Gabrio Roncucci
DOI: 10.1016/S1011-1344(01)00184-1
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摘要: Abstract A synthetic procedure has been developed for the preparation of a Zn-phthalocyanine peripherally substituted with dodecaborane. The absorption spectrum derivative is typical phthalocyanine chromophore. Moreover, boronated exhibits high photosensitizing efficiency against model biological substrate, such as N-acetyl- l -tryptophanamide, and singlet oxygen quantum yield 0.53 in dimethylformamide. Even though presence dodecaborane moiety appears to decrease affinity HT-1080 transformed human fibroblasts, causes an essentially complete loss cell viability upon irradiation 600–700 nm light under mild conditions (1 μM concentration, 5-min at 10 mW/cm2).
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