Boronated metal-phthalocyanines, process for their preparation, pharmaceutical compositions comprising them and use thereof
作者： Gabrio Roncucci , Moira Municchi , Giulio Jori , Giacomo Chiti , Donata Dei
DOI:
关键词: Metal 、 Combinatorial chemistry 、 Stereochemistry 、 Materials science
摘要: The present invention relates to meta l-phthalocyanines bearing at least a group containing boron isotopes 11B or 10B, covalently bound the peripheral positions of metal-phthalocyanine nucleus; moreover it refers processes for their preparation, pharmaceutical compositions comprising them and use treatment neoplastic dysplastic pathologies.
lens.org 参考文章(11)
Gabrio Roncucci, Barbara Cosimelli, Maria Paola De Filippis, Donata Dei, Lia Fantetti, Ilaria Masini, Giulio Jori, Zinc-phthalocyanines and corresponding conjugates, their preparation and use in photodynamic therapy and as diagnostic agents ,(1998)
Synthesis of soluble halogenated aryloxy substituted indium phthalocyanines Journal of The Chemical Society-perkin Transactions 1. pp. 91- 96 ,(2002) , 10.1039/B107689M
Stephen B. Kahl, Jing Li, Synthesis and Characterization of a Boronated Metallophthalocyanine for Boron Neutron Capture Therapy. Inorganic Chemistry. ,vol. 35, pp. 3878- 3880 ,(1996) , 10.1021/IC9600240
J. S. Hill, S. B. Kahl, S. S. Stylli, Y. Nakamura, M. S. Koo, A. H. Kaye, Selective tumor kill of cerebral glioma by photodynamic therapy using a boronated porphyrin photosensitizer Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 12126- 12130 ,(1995) , 10.1073/PNAS.92.26.12126
Clara Fabris, Giulio Jori, Francesca Giuntini, Gabrio Roncucci, Photosensitizing properties of a boronated phthalocyanine: studies at the molecular and cellular level. Journal of Photochemistry and Photobiology B-biology. ,vol. 64, pp. 1- 7 ,(2001) , 10.1016/S1011-1344(01)00184-1
M.Graça H Vicente, Shankar J Shetty, Anura Wickramasinghe, Kevin M Smith, Syntheses of carboncarbon linked carboranylated porphyrins for boron neutron capture therapy of cancer Tetrahedron Letters. ,vol. 41, pp. 7623- 7627 ,(2000) , 10.1016/S0040-4039(00)01346-0
Elisabetta Friso, Gabrio Roncucci, Donata Dei, Marina Soncin, Clara Fabris, Giacomo Chiti, Paolo Colautti, Juan Esposito, Laura De Nardo, Carlo Riccardo Rossi, Donato Nitti, Francesca Giuntini, Lara Borsetto, Giulio Jori, A novel 10B-enriched carboranyl-containing phthalocyanine as a radio- and photo-sensitising agent for boron neutron capture therapy and photodynamic therapy of tumours: in vitro and in vivo studies. Photochemical and Photobiological Sciences. ,vol. 5, pp. 39- 50 ,(2006) , 10.1039/B506364G
Gerald McMahon, VEGF Receptor Signaling in Tumor Angiogenesis Oncologist. ,vol. 5, pp. 3- 10 ,(2000) , 10.1634/THEONCOLOGIST.5-SUPPL_1-3
TARAK D. MODY, Pharmaceutical development and medical applications of porphyrin-type macrocycles Journal of Porphyrins and Phthalocyanines. ,vol. 4, pp. 362- 367 ,(2000) , 10.1002/(SICI)1099-1409(200006/07)4:4<362::AID-JPP250>3.0.CO;2-Z
VLADIMIR I. BREGADZE, IGOR B. SIVAEV, DETLEF GABEL, DIETER WÖHRLE, Polyhedral boron derivatives of porphyrins and phthalocyanines Journal of Porphyrins and Phthalocyanines. ,vol. 5, pp. 767- 781 ,(2001) , 10.1002/JPP.544