Germ cells microsatellite instability. The effect of different mutagens in a mismatch repair mutant of Drosophila (spel1).
作者： A López , N Xamena , R Marcos , A Velázquez , None
DOI: 10.1016/S1383-5718(01)00325-4
关键词:
摘要: Abstract Mismatch repair (MMR) process confers a type of genomic stability that maintains stable single repeated sequences, hence failure this could deviate in cancer development. A characteristic phenotype MMR-deficient cells is microsatellite instability (MSI) be modulated by mutagenic agents. The induction MSI the mutagens, bleomycin (BLM), hydrogen peroxide (H2O2), 2-acetylaminofluorene (2-AAF) and ethidium bromide (EB) was evaluated vivo, using Drosophila melanogaster-null mutant msh2 mismatch gene (spel1). Whereas germ spel1 strain, we found mutations five sequences studied untreated individuals, no alterations were MMR-proficient strain. On other hand, data obtained from treatment experiments show BLM 2-AAF induced slight effect background but not normal one. These results indicate use (MMR-deficient) relevant importance to identify environmental factors involved carcinogenesis processes through instability.
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