Microsatellite Instability and K-ras Mutations Associated with Pancreatic Adenocarcinoma and Pancreatitis

摘要: ras oncogene mutations and microsatellite instability (MIN) have been described in pancreatic cancer studies from paraffin blocks fresh frozen tissue. We sought to determine whether they could be detected endoscopic retrograde cholangiopancreatography-derived juice. were the juice of 40% (2 5) patients with 2 5 pancreatitis. MIN was at a single locus > or = loci 100% pancreatitis patients. The finding specimens verified performed on blocks. not normal pancreas controls. All who had their also evidence one more (P < 0.05), suggesting that is associated development mutation. More importantly, suggests can occur nonneoplastic conditions may represent saturation an intact mismatch repair system.