Microsatellite instability is absent in liver and biliary mucosa of patients with primary sclerosing cholangitis.

摘要: Microsatellite instability occurs in the colonic mucosa of patients with inflammatory bowel disease and may predispose to neoplastic transformation. It is unknown whether microsatellite also plays a role risk associated primary sclerosing cholangitis. We examined 134 tissue samples from 21 cholangitis for at eight loci. All tissues were stained immunohistochemically using an antibody proliferation marker Ki-67. did not occur any intrahepatic or extrahepatic biliary system, although one patient demonstrated colon. Ki-67 indices ranged 0 2.5 nondysplastic epithelium 1.5 29.4 areas dysplasia. The absence suggests that genetic basis progression chronic bile ducts differs intestinal cancers arising setting relate differences microenvironment these two sites.