The localization of aggregated human -globulin in the spleens of normal mice.

摘要: The localization of aggregated human γ-globulin in the germinal centres white pulp spleens normal mice was found to be dependent on ability spleen concentrate this material from blood and lymphoid cells mantle layer Malpighian bodies take it up their surface membranes. fact that resident perform function shown by inability transferred recipient animals transport latter. Ionizing radiation relatively high doses prevented effective only when given before or less than 6 hours after administration material. Spleens shielded during whole body irradiation were capable localizing centres, but local with protection rest splenic localization. These results support conclusion altered heterologous antibody is a already present at time injection not its into migrating which pick elsewhere. Antilymphocytic serum also γ-globulin, suggesting direct effect antiserum non-circulating cells. However, manner action requires further study.