T- and B-Areas in Immune Reactions Volume Changes in T and B Cell Compartments of the Rat Spleen Following Intravenous Administration of a Thymus-Dependent (SRBC) and a Thymus-Independent (Paratyphoid Vaccin-Endotoxin) Antigen. A Histometric Study

摘要: Abstract In the white pulp of rat spleens cell numbers were studied in different compartments following intravenous administration comparable doses paratyphoid vaccine (PTV, thymus-independent) and sheep red blood cells (SRBC, thymus-dependent). periarteriolar lymphatic sheaths (PALS) both concentration volume measured. For follicles marginal zone only was recorded first 5 days antigen administration. Additionally, histologic observations made. thymusdependent area PTV caused oedema 12–24 hours after Following SRBC an increase lymphocyte occurred until second day, probably representing influx T from recirculating pool. Both antigens gave rise to a plasmacellular reaction peripheral PALS (2 nd -4 th day). bone marrow-dependent areas massive shift medium-sized lymphocytes took place 24 These subsequently transformed into blasts. After (6 12 hours) few seemed migrate follicles. It is aruged that endotoxin present responsible for fact that, antigen, all (B) responded. Endotoxin stimulation might provide model fate stimulated by other agents, such as (stimulating binding B cells) or antigen-antibody complexes Fc-receptor cells).