Genomic and epigenetic characterization for the comparison of synchronous bilateral tongue squamous cell carcinomas—A case report

摘要: Abstract The tongue is the most common and aggressive site for tumors in oral cavity. These are usually located lateral border of often related to use tobacco alcohol. Clinical management these predominantly based on anatomic location TNM classification. identification molecular signatures with ability explain different outcomes observed patients paramount importance guide help their management. Case presentation : we herein describe an 88-year-old woman diagnosed synchronous bilateral carcinoma. This did not present traditional risk factors cancer—alcohol, tobacco, or presence human papiloma virus (HPV). Both were classified by a pathologist as pT2. patient was submitted surgery, 6 months later cervical metastasis following 2 died. Copy number alterations methylation status simultaneous analyzed using array comparative genomic hybridization, multiplex ligation-dependent probe amplification, specific amplification. In conclusion , both identified several traits found among cavity some those have been associated clinical outcome, reinforcing accurately establish biomarkers applicability. Specific epigenetic each also allowing discrimination. tumor right side exhibited more copy gains than left side. less smaller methylated genes observed, which could be indicative early phase development. case shows heterogeneity even same site, key patients.