The role of MRI and MRS in the diagnosis of non hydrocephalic macrocrania in infancy and early childhood

摘要: Abstract The aim of this study was to determine the key MRI findings in different disease causing macrocrania early childhood that will help detection and diagnosis. Patients methods This conducted on 20 patients (their age ranged from 3.5 months 5 years) referred radiodiagnosis department period between February 2013 June 2014. All were subjected conventional MRI. MRS done 8 cases using PRESS 3D multi-voxel chemical shift imaging. Results subdivided into 7 groups. Glutaric aciduria type 1 (40%) showed wide operculum sign; 4 elevated choline with preserved NAA peak. Benign infancy (15%), enlarged cranio-cortical inter-hemispheric subarachnoid spaces beyond 5 mm, mildly dilated ventricles. Van der Knaap (15%) bilateral symmetrical confluent white matter dysmyelination fronto-temporal subcortical cystic changes .MRS 2 increase Cho/NAA ratios. Mucopolysaccharidosis (10%) Virchow Robin spaces. one patient decreased NAA, increased choline/creatine ratio. Canavan extensive dysmyelination. markedly NAA. Alexander (5%) frontal predilection. revealed NAA/Cr, myo-inositol/Cr, lactate doublet. Gangliosidosis T2 FLAIR hyperintense putamen. CT symmetric thalamic hyperdensities. Conclusion can diagnose causes non hydrocephalic macrocrania. is helpful differentiating benign dysmyelinating diseases specific Disease.