Association between survivin gene promoter -31 C/G polymorphism and urothelial carcinoma risk in Taiwanese population.
作者： Yuan-Hung Wang , Hung-Yi Chiou , Chang-Te Lin , Hsiao-Yen Hsieh , Chia-Chang Wu
DOI: 10.1016/J.UROLOGY.2008.09.048
关键词:
摘要: Objectives To investigate the association between survivin gene promoter −31 C/G polymorphism and urothelial carcinoma (UC) risk in a Taiwanese population. Methods A total of 190 patients with pathologically confirmed UC 210 unrelated controls without cancer were recruited at Chiayi Christian Hospital from August 2002 to May 2007. The was determined using polymerase chain reaction-restriction fragment length analysis. Results Compared study subjects carrying G/G genotype, significantly increased risks found for individuals genotype (odds ratio 2.8; 95% confidence interval [CI] 1.7-4.6) those C/C 4.0; CI 2.3-7.2). Those or had 3.2 (95% 1.9-5.2) compared genotype. Among heavy smokers (≥30 pack-years), we 3.8 1.3-11.3) Furthermore, greater prevalence muscle-invasive (Stage T2-T4), high-grade (G3), invasive, tumor Conclusions These findings suggest that is associated both clinical stage pathologic grade might be involved development UC.
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