Silicon-based reproducible and active surface-enhanced Raman scattering substrates for sensitive, specific, and multiplex DNA detection

摘要: Silicon-based active and reproducible surface-enhanced Raman scattering (SERS) substrate, i.e., silver nanoparticles decorated-silicon wafers (AgNPs@Si), is employed for constructing high-performance sensors. Significantly, the AgNPs@Si, facilely prepared via in situ AgNPs growth on silicon wafers, features excellent SERS reproducibility high enhancement factor. Our experiment further demonstrates such resultant silicon-based substrate efficacious multiplex, sensitive, specific DNA detection. In particular, single-base mismatched with low concentrations readily discriminated by using AgNPs@Si. Moreover, sensor exhibits adequate multiplexing capacity, enabling unambiguous identification of dual-target