Neuropilin-1 contributes to esophageal squamous cancer progression via promoting P65-dependent cell proliferation.
作者： F Shi , L Shang , L-Y Yang , Y-Y Jiang , X-M Wang
DOI: 10.1038/ONC.2017.399
关键词:
摘要: Neuropilin-1 (NRP1) is a non-kinase receptor recently implicated in tumor progression. Here we revealed that over-expression of NRP1 correlates with poor prognosis esophageal squamous cell carcinoma (ESCC). NRP1-knockdown suppressed ESCC proliferation and xenograft growth. Reduced expression downregulated P65 mRNA protein expression, ectopic P65-restored NRP1-silenced cells. regulates transcription by activating cAMP responsive element binding (CREB). interacted activated epidermal growth factor (EGFR), b1/b2 domain responsible for the activation EGFR. We also found EGFR regulated CREB transcriptional activity via AKT. These data suggest an upstream regulator P65-dependent signaling pathway candidate therapeutic target ESCC.
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