Evaluation of a compact, high-resolution SPECT detector based on digital silicon photomultipliers

作者: Carmen Bouckaert , Stefaan Vandenberghe , Roel Van Holen

DOI: 10.1088/0031-9155/59/23/7521

关键词:

摘要: MicroSPECT is one of the main functional imaging techniques used in preclinical setting. Even though high-resolution images can be obtained with currently available systems, their sensitivity often quite low due to use multi-pinhole collimation. This results long acquisition times and hampers dynamic imaging. However, it has already been shown that this limited overcome using detectors. In article, we therefore investigated a digital photon counter (DPC) combination 2 mm thick monolithic LYSO crystal for SPECT These light sensors contain arrays avalanche photodiodes whose signals are directly digitised. The DPCs have advantage they very compact, high intrinsic resolution, MR compatible allow disabling cells dark count rate. order investigate influence temperature dependent rate on detector performance, compared at 3 °C 18 °C. At °C, observed an energy resolution 28.8% spatial 0.48 mm. Furthermore, 10% loss 60 kcps. Next, looked event caused by higher found 5% measurements. becomes 29.2% decreases 0.52 Due loss, increases 63 A small degradation performance thus °C.These show usefulness together its excellent resolution. drawback low, spatially varying detection efficiency better still acceptable

参考文章(42)
T. Frach, G. Prescher, C. Degenhardt, R. de Gruyter, A. Schmitz, R. Ballizany, The digital silicon photomultiplier — Principle of operation and intrinsic detector performance ieee nuclear science symposium. pp. 1959- 1965 ,(2009) , 10.1109/NSSMIC.2009.5402143
M C Goorden, M C M Rentmeester, F J Beekman, Theoretical analysis of full-ring multi-pinhole brain SPECT Physics in Medicine and Biology. ,vol. 54, pp. 6593- 6610 ,(2009) , 10.1088/0031-9155/54/21/010
Harrison H. Barrett, William C. J. Hunter, Brian William Miller, Stephen K. Moore, Yichun Chen, Lars R. Furenlid, Maximum-Likelihood Methods for Processing Signals From Gamma-Ray Detectors IEEE Transactions on Nuclear Science. ,vol. 56, pp. 725- 735 ,(2009) , 10.1109/TNS.2009.2015308
B. L. Franc, P. D. Acton, C. Mari, B. H. Hasegawa, Small-Animal SPECT and SPECT/CT: Important Tools for Preclinical Investigation The Journal of Nuclear Medicine. ,vol. 49, pp. 1651- 1663 ,(2008) , 10.2967/JNUMED.108.055442
C. Lackas, N.U. Schramm, J.W. Hoppin, U. Engeland, A. Wirrwar, H. Halling, T-SPECT: a novel imaging technique for small animal research ieee nuclear science symposium. ,vol. 52, pp. 181- 187 ,(2003) , 10.1109/TNS.2005.843615
Effects of dark counts on Digital Silicon Photomultipliers performance nuclear science symposium and medical imaging conference. pp. 1- 6 ,(2013) , 10.1109/NSSMIC.2013.6829323
Optimization of a stationary small animal SPECT system for simultaneous SPECT/MRI nuclear science symposium and medical imaging conference. pp. 1- 4 ,(2013) , 10.1109/NSSMIC.2013.6829145
Anca M. Avram, Ka Kit Wong, Lorraine M. Fig, SPECT/CT for Thyroid Cancer Imaging Springer, Berlin, Heidelberg. pp. 61- 85 ,(2014) , 10.1007/978-3-642-35283-6_4
A.B. Hwang, K. Iwata, B.H. Hasegawa, Simulation of depth of interaction effects for pinhole SPECT ieee nuclear science symposium. ,vol. 3, pp. 1293- 1297 ,(2001) , 10.1109/NSSMIC.2001.1008574