VEGF-C, VEGF-D and VEGFR-3 expression in peripheral neuroblastic tumours.

摘要: Ramani P, Nash R, Radevsky L, Patel A, Luckett M & Rogers C (2012) Histopathology VEGF-C, VEGF-D and VEGFR-3 expression in peripheral neuroblastic tumours Aims:  More than 50% of neuroblastomas (NBs) present with haematogenous and/or lymphatic metastasis; however, little is known about the clinicopathological significance NBs key lymphangiogenesis growth factors vascular endothelial factor (VEGF)-C receptor VEGFR-3. Methods results:  Ninety-three nine ganglioneuromas (GNs) were immunostained for VEGFR-3. VEGF-C 76% 82% NBs, respectively. There was no significant difference between GNs. significantly higher compared GNs MYCN-amplified NBs. tumoral cell (VEGFR-3c), 48% from children ≥18 months at presentation those belonging to a high-risk group. lymphovascular density increased associated adverse biological factors. Lymphovascular invasion, assessed VEGFR-3-stained vessels, ∼50% Cox regression analyses demonstrated that VEGFR-3c shorter event-free survival its effect independent important pathological variable, mitosis–karyorrhexis index. Conclusions:  up-regulation support tumour progression NB may provide useful prognostic marker