Methods of using CD8+/TCR- facilitating cells (FC) for the engraftment of purified hematopoietic stem cells (HSC)

摘要: The present invention relates to the identification and use of facilitating cells that are critical for engraftment purified “hematopoietic stem cells” (HSC), more specifically this two cell populations CD8 + cells, is, /TCR − “facilitating (FC) which (HSC) survival self-renewal, enhance level donor but do not promote long-term, durable engraftment. These may have a wide range applications, including limited to, hematopoietic reconstitution by bone marrow transplantation treatment cancers, anemias, autoimmunity, immunodeficiency, viral infections metabolic disorders as well facilitation solid organ, tissue cellular transplantation.