Beta2 toxin, a novel toxin produced by Clostridium perfringens.

摘要: A novel toxin (Beta2) and its gene were characterized from a Clostridium perfringens strain isolated piglet with necrotic enteritis. At the amino-acid level, Beta2 (27670 Da) has no significant homology previously identified Beta (called Beta1) (34861 kDa) C. type B NCTC8533 ( Hunter, S.E.C., Brown, J.E., Oyston, P.C.F., Sakurai, J., Titball, R.W., 1993. Molecular genetic analysis of beta-toxin reveals sequence alpha-toxin, gamma-toxin, leukocidin Staphylococcus aureus. Infect. Immun. 61, 3958-3965). Both Beta1 toxins lethal for mice cytotoxic cell line 1407, inducing rounding lysis without affecting actin cytoskeleton. The genes encoding have been localized in unlinked loci large plasmids perfringens. In addition, toxin-producing strains found to be associated animal diseases such as enteritis piglets enterocolitis horses.