Effect of rhBMP-2 on guided bone regeneration in humans

摘要: The aim of the present clinical study was to test whether or not addition recombinant human bone morphogenetic protein-2 (rhBMP-2) a xenogenic substitute mineral (Bio-Oss) will improve guided regeneration therapy regarding volume, density and maturation. In 11 partially edentulous patients, 34 Branemark implants were placed at two different sites in same jaw (five maxillae, six mandibles) requiring lateral ridge augmentation. defects randomly assigned control treatments: both augmented with resorbable collagen membrane (Bio-Gide). At sites, coated rhBMP-2 lyophilization process. Following implant insertion (baseline), peri-implant defect height measured from shoulder first implant-bone contact. After an average healing period 6 months (SD 0.17, range 5.7-6.2), residual again trephine burs used take 22 biopsies regions. uneventful except for one site that showed wound dehiscence, which spontaneously closed after 4 weeks. Later reentry, all stable. baseline, mean 7.0 mm 2.67, 3-12 mm) 5.8 1.81, 3-8 sites. decreased 0.2 0.35, 0-1 (corresponding 96% vertical fill) 0.4 0.66, 0-2 (vertical fill 91%). Reduction baseline reentry statistically significant (Wilcoxon P<0.01). Histomorphometric analysis area 37% 11.2, 23-51%) newly formed 30% 8.9, 18-43%) fraction mineralized identified as mature lamellar amounted 76% 14.4, 47.8-94%) compared 56% 18.3, 31.6-91.4%) (paired t-test P<0.05). BMP-treated 57% 16.2, 29-81%) 22.6, 0-66%) surface particles direct contact It is concluded combination can enhance maturation process increase graft humans. has potential predictably accelerate therapy.