Carcinosarcoma of the liver producing granulocyte-colony stimulating factor
作者： Kumi Aita , Kunihiko Seki
DOI: 10.1111/J.1440-1827.2006.01979.X
关键词:
摘要: An autopsy case of carcinosarcoma the liver producing granulocyte-colony stimulating factor (G-CSF) is reported. The patient, a 74-year-old Japanese man, presented with multiple masses. His serum G-CSF was elevated to 286 pg/mL and marked leukocytosis 19 100/microL observed. patient had rapidly aggravated clinical course died 57 days after admission. Autopsy revealed composed both hepatocellular carcinoma (HCC) sarcomatous elements immunoreactive alpha-smooth muscle actin desmin. Immunohistochemistry positive staining in cytoplasm HCC, whereas none spindle cells positively stained. Production also confirmed by enzyme-linked immunosorbent assay, using frozen tumor tissue taken at autopsy. Similar majority G-CSF-producing tumors literature, only epithelial present were immunopositive for G-CSF. Although monoclonal origin carcinosarcomas has generally been proposed, heterologous differentiation from single clone might lead production element case. It suggested that associated high-grade transformation elements, as well reported phenomenon conventional HCC
sci-hub.se 参考文章(17)
S Asano, A Urabe, T Okabe, N Sato, Y Kondo, Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood. ,vol. 49, pp. 845- 852 ,(1977) , 10.1182/BLOOD.V49.5.845.845
Hiroshi Tazaki, Ayako Miyakawa, Masaaki Tachibana, Atsushi Kubo, Kayoko Nakamura, Jun-ichi Hata, Yasuhiro Amano, Tatsunari Nishi, Autocrine growth of transitional cell carcinoma of the bladder induced by granulocyte-colony stimulating factor Cancer Research. ,vol. 55, pp. 3438- 3443 ,(1995)
Motoko Sasaki, Koichi Tsuneyama, Akira Ishikawa, Yasuni Nakanuma, Intrahepatic cholangiocarcinoma in cirrhosis presents granulocyte and granulocyte-macrophage colony-stimulating factor. Human Pathology. ,vol. 34, pp. 1337- 1344 ,(2003) , 10.1016/J.HUMPATH.2003.07.012
Sumie Yamamoto, Shuji Takashima, Hiroyuki Ogawa, Toshifumi Kuroda, Mitsunari Yamamoto, Akira Takeda, Hideji Nakmaura, Granulocyte-colony-stimulating-factor-producing hepatocellular carcinoma Journal of Gastroenterology. ,vol. 34, pp. 640- 644 ,(1999) , 10.1007/S005350050387
Akishi Ooi, Shogo Katsuda, Isao Nakanishi, Noriko Nakamura, Fumiaki Matsushita, Nobuyoshi Tanaka, Kenichi Kobayashi, HEPATOCELLULAR CARCINOMA WITH CHONDROSARCOMATOUS VARIATION Pathology International. ,vol. 37, pp. 1165- 1173 ,(1987) , 10.1111/J.1440-1827.1987.TB00434.X
Tatsuhiko HAYASHI, Akira MIZUKI, Takuya YAMAGUCHI, Tasuku HASEGAWA, Takamu KUNIHIRO, Nobuhiro TSUKADA, Kentaro MATSUOKA, Hideki ORIKASA, Kazuto YAMAZAKI, Primary Adenosquamous Carcinoma of the Liver Which Produces Granulocyte-Colony-Stimulating Factor and Parathyroid Hormone Related Protein: Association with Leukocytosis and Hypercalcemia Internal Medicine. ,vol. 40, pp. 631- 634 ,(2001) , 10.2169/INTERNALMEDICINE.40.631
KIYOSHI HIRASAWA, TADAICHI KITAMURA, TERUAKI OKA, HIROSHI MATSUSHITA, Bladder Tumor Producing Granulocyte Colony-Stimulating Factor and Parathyroid Hormone Related Protein The Journal of Urology. ,vol. 167, pp. 2130- 2130 ,(2002) , 10.1016/S0022-5347(05)65104-X
Tetsuo Ikeda, Kippei Ohgaki, Masatoku Miura, Shinichi Aishima, Toshihisa Shimizu, Yoshihiko Maehara, Granulocyte-colony stimulating factor-producing gallbladder cancer without recurrence more than 2 years after resection: report of a case. Surgery Today. ,vol. 35, pp. 590- 593 ,(2005) , 10.1007/S00595-004-2981-4
Fayyazi, Nolte, Oestmann, Sattler, Ramadori, Radzun, Carcinosarcoma of the liver Histopathology. ,vol. 32, pp. 385- 387 ,(1998) , 10.1046/J.1365-2559.1998.0401J.X
Hitoshi Kubosawa, Hideo Ishige, Yoichiro Kondo, Akio Konno, Tsukasa Yamamoto, Koichi Nagao, Hepatocellular carcinoma with rhabdomyoblastic differentiation Cancer. ,vol. 62, pp. 781- 786 ,(1988) , 10.1002/1097-0142(19880815)62:4<781::AID-CNCR2820620423>3.0.CO;2-T