Excitation of mammalian central neurones by acidic amino acids.

摘要: Abstract An investigation was made of the mechanism depolarization spinal motoneurones by excitant amino acids, and possible antagonists excitation spinal, thalamic cerebral cortical neurones these substances. The dl -homocysteate not altered changes in intracellular chloride concentration, or extracellular concentrations tetrodotoxin sufficient to suppress spike generation. action acid thus probably resembles that synaptically released excitatory transmitters. Of a number substances tested only l -glutamic diethyl ester, -methionine- -sulphoximine 2-methoxy-aporphine reduced sensitivity ventrobasal thalamic, lateral geniculate -glutamate, -aspartate without influencing acetylcholine. spontaneous synaptic firing were markedly antagonists. However, because technical difficulties lack selectivity antagonism evoked -glutamate -aspartate, considered unsuitable for investigating pathways which may use either acids as