Correlates of IL-10 and IL-12 concentrations in cervical secretions.

摘要: Interindividual variations in host immune responses to HPV infection are thought be important determinants of viral persistence and progression cervical intraepithelial neoplasia cancer. However, few studies have measured local markers at the site (e.g., mucosa). We sought determine biologic correlates IL-10 IL-12 concentrations secretions. Cervical secretions were passively collected using a WeckCel sponge from 247 women participating natural history study human papillomavirus as part an immunologic ancillary study. determined standard ELISA assays.In general, levels significantly intercorrelated (Pearson's correlation coefficient = 0.6) but had somewhat different determinants. Significant increases (P < 0.05) observed for nonovulatory phases menstrual cycle, postmenopausal status, recent use oral contraceptives (OC), low secretion volume, macrolevels heme contamination, high vaginal pH. Increasing also among smokers, with increasing numbers lifetime sex partners, who report having less frequent (less than once per week), however, these results not statistically significant. Significantly higher OC users, There was non-statistically significant observation nonsmokers, pregnancies, contamination. failed observe association between or this cross-sectional sample. Future analyses cytokine should control inherent variation due hormonal influences, hemoglobin pH, volume differences.