Major Histocompatibility Complex Class II Polymorphisms and Risk of Cervical Cancer and Human Papillomavirus Infection in Brazilian Women

摘要: Infection with high-risk human papillomavirus (HPV) is the major risk factor for development of malignant lesions in uterine cervix. Environmental, behavioral, and ill-defined genetic factors also have been implicated pathogenesis this disease. Associations between leukocyte antigens (HLAs) cervical cancer, precursor lesions, HPV infections reported several populations. To verify whether HLA-DRB1 , -DQA1 -DQB1 diversity related to cancer Brazilian population, 161 cases 257 controls were HLA typed. Variants DQA1 DQB1 promoter regions typed 92 228 controls. Polymorphism genes promoters was distinguished by PCR-based methods, magnitude associations determined logistic regression analysis. DRB1*15 [ confounder-adjusted odds ratio (OR), 2.24; 95% confidence interval (CI), 1.29–3.90], DRB1*1503 (OR, 2.52; CI, 1.16–5.48), haplotype DRB1\*15-DQB1\*0602 2.04; 1.15–3.61) positively associated cancer. When we considered only DR15 haplotypes that did not carry DQB1*0602 allele, attributed more than doubled. A negative association found DQB1*05 0.57; 0.35–0.92), similar trends observed DQA1*0101/04 DRB1*0101, DRB1*1302 . positivity among 4.60; 1.33–15.9), DRB1*0405 6.21; 1.66–23.2), 2.48; 1.06–5.80). We suggest class II polymorphisms are involved susceptibility infection a population from an area high incidence neoplasia.