Integrative approach using liver and duodenum RNA-Seq data identifies candidate genes and pathways associated with feed efficiency in pigs.

摘要: This study aims identifying candidate genes and pathways associated with feed efficiency (FE) in pigs. Liver duodenum transcriptomes of 37 gilts showing high low residual intake (RFI) were analysed by RNA-Seq. Gene expression data was explored through differential (DE) weighted gene co-expression network analyses. DE analysis revealed 55 112 differentially regulated liver tissues, respectively. Clustering according to their connectivity resulted 23 (liver) 25 (duodenum) modules a pattern. Four modules, one (with 444 co-expressed genes) three (gathering 37, 126 41 genes), significantly FE indicators. Intra-module analyses tissue-specific genes; 12 these also identified as between individuals RFI. Pathways enriched the list and/or belonging included response oxidative stress, inflammation, immune response, lipid metabolism thermoregulation. Low overlapping tissues observed but heat shock proteins both tissues. Our results suggest rather than common transcriptome regulatory processes