Oncogenic effects of WNT5A in Epstein-Barr virus‑associated nasopharyngeal carcinoma
作者： LEE FAH YAP , MUNIRAH AHMAD , MUHAMMAD MAMDUH AHMAD ZABIDI , TAI LIN CHU , SAN JIUN CHAI
关键词:
摘要: The molecular events that drive the progression of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) are still to be elucidated. Here, we report for first time pathogenic significance an NPC-associated gene, wingless-type MMTV integration site family, member 5A (WNT5A) and contribution EBV its expression. WNT5A is a representative Wnt protein activates non-canonical signalling. With regard role in carcinogenesis, there conflicting evidence as whether has tumour-promoting or tumour-suppressive role. We show upregulated primary NPC tissue samples. also demonstrate expression was dramatically increased cell lines expressing EBV-encoded LMP2A suggesting this latent gene responsible upregulating NPC. In addition, vitro overexpression promotes proliferation, migration invasion cells. Our results not only reveal pro-tumorigenic effects but suggest could important therapeutic target patients with EBV-associated disease.
sci-hub.se 参考文章(45)
KC Pua, AS Khoo, YY Yap, SK Subramaniam, CA Ong, G Gopala Krishnan, None, Nasopharyngeal Carcinoma Database. The Medical journal of Malaysia. pp. 59- 62 ,(2008)
Pär-Ola Bendahl, Marzieh Jönsson, Janna Dejmek, Tommy Andersson, Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. Cancer Research. ,vol. 62, pp. 409- 416 ,(2002)
Mimi C. Yu, Jian-Min Yuan, Epidemiology of nasopharyngeal carcinoma. Seminars in Cancer Biology. ,vol. 12, pp. 421- 429 ,(2002) , 10.1016/S1044579X02000858
Etienne Blanc, Gwenaëlle Le Roux, Jean Bénard, Gilda Raguénez, Low expression of Wnt-5a gene is associated with high-risk neuroblastoma. Oncogene. ,vol. 24, pp. 1277- 1283 ,(2005) , 10.1038/SJ.ONC.1208255
Philip D. Da Forno, J. Howard Pringle, Peter Hutchinson, Joy Osborn, Qiang Huang, Linda Potter, Rachael A. Hancox, Alan Fletcher, Gerald S. Saldanha, WNT5A Expression Increases during Melanoma Progression and Correlates with Outcome Clinical Cancer Research. ,vol. 14, pp. 5825- 5832 ,(2008) , 10.1158/1078-0432.CCR-07-5104
Dexing Qin, Yuhua Hu, Jiehua Yan, Guozhen Xu, Weiming Cai, Xuelin Wu, Dexian Cao, Xianzhi Gu, Analysis of 1379 patients with nasopharyngeal carcinoma treated by radiation Cancer. ,vol. 61, pp. 1117- 1124 ,(1988) , 10.1002/1097-0142(19880315)61:6<1117::AID-CNCR2820610611>3.0.CO;2-J
Cary A. Moody, Rona S. Scott, Nazanin Amirghahari, Cherie-Ann Nathan, Lawrence S. Young, Chris W. Dawson, John W. Sixbey, Modulation of the Cell Growth Regulator mTOR by Epstein-Barr Virus-Encoded LMP2A Journal of Virology. ,vol. 79, pp. 5499- 5506 ,(2005) , 10.1128/JVI.79.9.5499-5506.2005
Chunfang Hu, Wenbin Wei, Xiaoyi Chen, Ciaran B. Woodman, Yunhong Yao, John M. Nicholls, Irène Joab, Sim K. Sihota, Jian-Yong Shao, K. Dalia Derkaoui, Aicha Amari, Stephanie L. Maloney, Andrew I. Bell, Paul G. Murray, Christopher W. Dawson, Lawrence S. Young, John R. Arrand, A global view of the oncogenic landscape in nasopharyngeal carcinoma: an integrated analysis at the genetic and expression levels. PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0041055
PG Murray, CB Woodman, T Stankovic, SH Teo, LS Young, PV Lim, J Arrand, W Wei, M Buettner, E Maina, MB Chukwuma, C Dawson, S Morgan, A Saleh, J Starzcynski, M Fung, LF Yap, S Bose, The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma The Journal of Pathology. ,vol. 217, pp. 345- 352 ,(2009) , 10.1002/PATH.2487
Mariana Fernandez-Cobo, Francesca Zammarchi, John Mandeli, James Holland, Beatriz Pogo, Expression of Wnt5A and Wnt10B in non-immortalized breast cancer cells. Oncology Reports. ,vol. 17, pp. 903- 907 ,(2007) , 10.3892/OR.17.4.903