Granulocytär anaplasmos hos hund
作者： Elin Liljeroth
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摘要: Granulocytar anaplasmos orsakas av den gramnegativa bakterien Anaplasma phagocytophilum, som sprids via fastingarten Ixodes ricinus. Det har visats att denna fastingart okat och spridits norrut i Sverige, dar tidigare inte funnits lika stor utstrackning pa grund ett for kallt klimat. Orsaken till spridningen ar troligen klimatforandringar, da Sveriges medeltemperatur stigit under en langre period. Sjukdomen kan drabba manga vara husdjur men aven manniskan. De vanligaste kliniska symptom uppkomma feber, dalig aptit slohet. A. phagocytophilum infekterar neutrofiler flertalet mekanismer paverkar neutrofilens funktioner negativt, vilket sin tur forsamrar vardens immunforsvar. Exempel mekanismerna blockering NADPH oxidas, fordrojning apoptos utbyte olika yt-antigen. finns metoder detektera bakterien: PCR, serologi blodutstryk. Vid PCR anvands oftast generna 16S rRNA eller msp2 phagocytophilum. utvecklats realtids-PCR, detektion bakterie, metoden bade kansligare mer effektiv. behandlas med antibiotika, vanligtvis doxycycline tetracycline. medlet marknaden forebygga infektion scalibor®, halsband utsondrar amne over pals hud, dodar fastingen forhindrar overforing bakterien.
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