c-erbB-2 is not a major factor in the development of colorectal cancer.

摘要: We have investigated c-erbB-2 protein expression in a large cohort of well-characterized colorectal tumours, and subset lymph node metastases. also evaluated Val655Ile single nucleotide polymorphism, which is associated with an increased risk breast cancer, the cancer patients healthy control subjects. Immunohistochemical studies revealed that while 81.8% tumours expressed c-erbB-2, majority cases equivalent levels c-erb-B2 were seen adjacent normal mucosa. Colon significantly more likely to express than rectal (P=0.015). Only 52.4% metastases displayed staining patterns concordant their primary tumour, indicating determination cannot predict status PCR–RFLP analysis polymorphism demonstrated allele frequencies identical between group Caucasian subjects (Ile=0.80 Val=0.20 each case), it not related developing this population. Furthermore, there was no relationship gene (P=0.58). In terms prognosis, association either or presence Val patient survival (P>0.05 suggesting prognostic marker cancer.